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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T20759 XRP44X

XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Ras GPCR/G Protein; MAPK
XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂,IC50为 10 nM,通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T69195 UC-857993

UC-857993 是一种选择性SOS1-Ras 抑制剂 (Kd=14.7 μM, His6-SOS1cat),抑制其催化活性。UC-857993 还能抑制ERKRas 激活,抑制小鼠胚胎成纤维细胞 (MEF) 的生长。
T37422 Ras Inhibitory Peptide

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ...
T71163 Pimasertib HCl

Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activati...

化合物

XRP44X
Cat.No: T20759
Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X
Target: Ras
UC-857993
Cat.No: T69195
Synonym:
Target:
Ras Inhibitory Peptide
Cat.No: T37422
Synonym:
Target:
Pimasertib HCl
Cat.No: T71163
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN2114 Pseudoginsenoside Rh2

拟人参皂苷RH2,拟人参皂苷 Rh2

ERK; Raf; p53 Apoptosis; MAPK
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity.

天然产物

Pseudoginsenoside Rh2
Cat.No: TN2114
Synonym: 拟人参皂苷RH2,拟人参皂苷 Rh2
Target: ERK, Raf, p53
TargetMol Loading
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